解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
医学,研究和试验
神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
精神病学
公共、环境和职业卫生
放射学,核医学和医学成像
康复学
生殖生物学
呼吸系统
风湿病学
运动科学
外科学
毒理学
热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract::A mathematical model is presented that estimates joint kinematics and kinetics using measured external resultant loads and readily available parameters. The musculo-skeletal system was represented by a planar three degrees of freedom open kinematic chain. Information extraction was limited to the flexion-extension fun...
journal_title:Annals of biomedical engineering
pub_type: 临床试验,杂志文章
doi:10.1023/b:abme.0000030241.26857.75
更新日期:2004-05-01 00:00:00
abstract::Basic fibroblast growth factor (FGF-2) is a potent angiogenic growth factor involved in the development of diseases such as cancer, atherosclerosis, and heart and limb ischemia, as well as normal wound healing and tissue development. Despite being one of the most heavily studied angiogenic growth factors, the binding ...
journal_title:Annals of biomedical engineering
pub_type: 杂志文章
doi:10.1023/b:abme.0000030231.88326.78
更新日期:2004-05-01 00:00:00
abstract::In uniaxial tensile testing, load preconditioning is used to generate repeatable load/elongation curves and set a "reference state" for subsequent tensile tests. We have observed however, that for porcine aortic valve (PAV) tissues, preconditioning does not lead to repeatable stress relaxation curves. We thus investig...
journal_title:Annals of biomedical engineering
pub_type: 杂志文章
doi:10.1023/b:abme.0000019176.49650.19
更新日期:2004-04-01 00:00:00
abstract::The current paradigm in tissue engineering is that "full regeneration" or "total replacement" of normal tissue is required in order to restore joint function. However, there is considerable evidence that suggests that targets other than "normality" may actually be required for tissue substitutes. Sometimes "less than ...
journal_title:Annals of biomedical engineering
pub_type: 杂志文章,评审
doi:10.1023/b:abme.0000017548.85451.b7
更新日期:2004-03-01 00:00:00
abstract::Step-off edges and tissue interfaces are prevalent in cartilage injury such as after intra-articular fracture and reduction, and in focal defects and surgical repair procedures such as osteochondral graft implantation. It would be useful to assess the function of injured or donor tissues near such step-off edges and t...
journal_title:Annals of biomedical engineering
pub_type: 杂志文章
doi:10.1023/b:abme.0000017553.01798.12
更新日期:2004-03-01 00:00:00
abstract::Knowledge of strain-rate sensitivity of soft tissue viscoelastic and nonlinear elastic properties is important for accurate predictions of biomechanical behavior and for quantitative assessment of the effects of disease or surgical/pharmaceutical intervention. Soft tissues are known to exhibit mild rate sensitivity, b...
journal_title:Annals of biomedical engineering
pub_type: 杂志文章
doi:10.1023/b:abme.0000012742.01261.b0
更新日期:2004-02-01 00:00:00
abstract::The field of tissue engineering promises to deliver biological substitutes to repair or replace tissues in the body that have been injured or diseased. The clinical demand for musculoskeletal tissues is particularly high, especially for cartilage and bone defects. Although they are generally considered biologically si...
journal_title:Annals of biomedical engineering
pub_type: 杂志文章,评审
doi:10.1023/b:abme.0000007799.60142.78
更新日期:2004-01-01 00:00:00
abstract::Deformational loading represents a primary component of the chondrocyte physical environment in vivo. This review summarizes our experience with physiologic deformational loading of chondrocyte-seeded agarose hydrogels to promote development of cartilage constructs having mechanical properties matching that of the par...
journal_title:Annals of biomedical engineering
pub_type: 杂志文章,评审
doi:10.1023/b:abme.0000007789.99565.42
更新日期:2004-01-01 00:00:00
abstract::A mathematical model of heat, water and soluble gas exchange in the airways and alveoli was used to predict the location of soluble gas exchange in the lung. A previously published model of heat, water and soluble gas exchange in the airways was improved by incorporating anatomical data on the airway wall to better de...
journal_title:Annals of biomedical engineering
pub_type: 杂志文章
doi:10.1114/1.1630600
更新日期:2003-12-01 00:00:00
abstract::We attempted to estimate in living adherent epithelial alveolar cells, the degree of structural and mechanical heterogeneity by considering two individualized cytoskeleton components, i.e., a submembranous "cortical" cytoskeleton and a "deep" cytoskeleton (CSK). F-actin structure characterizing each CSK component was ...
journal_title:Annals of biomedical engineering
pub_type: 杂志文章
doi:10.1114/1.1616932
更新日期:2003-11-01 00:00:00
abstract::The effects of tissue hydration and fixed charge density on hydraulic permeability and creep behavior of cartilaginous tissues have been investigated using the triphasic theory and finite element methods. The empirical model for hydraulic permeability of uncharged gels and Mackie and Meares (1955) model for ion diffus...
journal_title:Annals of biomedical engineering
pub_type: 杂志文章
doi:10.1114/1.1615576
更新日期:2003-11-01 00:00:00
abstract::Vibration under shear flow causes the reduction of flow resistance for shear-thinning fluids. The present study investigates the effect of vibration on the flow resistance of a nonaggregating red blood cell (RBC) suspension with a newly designed pressure-scanning capillary viscometer (PSCV). The PSCV was originally de...
journal_title:Annals of biomedical engineering
pub_type: 杂志文章
doi:10.1114/1.1603751
更新日期:2003-10-01 00:00:00
abstract::We present a method of measuring force response of a single living cell, attached to a substrate, in situ, by a functionalized microelectromechanical systems sensor that applies local deformation on the cell. The sensor is a single crystal silicon microcantilever beam with prescribed shape and geometry, and is coated ...
journal_title:Annals of biomedical engineering
pub_type: 杂志文章
doi:10.1114/1.1591189
更新日期:2003-09-01 00:00:00
abstract::Understanding the complex spatiotemporal dynamics of action potential propagation in the heart during arrhythmia is exceedingly difficult. This study applies nonlinear dynamics tools to simplify this task. Using the results of a simulation of an electrical induction of reentry in a sheet of myocardium represented as a...
journal_title:Annals of biomedical engineering
pub_type: 杂志文章
doi:10.1114/1.1581289
更新日期:2003-07-01 00:00:00
abstract::The epidermal growth factor (EGF) is a growth factor with effects on many cell types and tissue. Morphometric and passive biomechanical properties were studied in isolated segments of the esophagus in 22 EGF-treated rats and 12 control rats. The rats were divided into groups with EGF treatment for 2, 4, 7, and 14 days...
journal_title:Annals of biomedical engineering
pub_type: 杂志文章
doi:10.1114/1.1575758
更新日期:2003-06-01 00:00:00
abstract::We propose a new method for guiding catheter ablation procedures to abolish sites of origin of arrhythmias. This method models both cardiac electrical activity and current pulses delivered from the tip of the ablation catheter with a single equivalent moving dipole (SEMD). The SEMD parameters are obtained from analysi...
journal_title:Annals of biomedical engineering
pub_type: 杂志文章
doi:10.1114/1.1567281
更新日期:2003-05-01 00:00:00
abstract::Biochemical stimulation was applied in combination with cyclic mechanical strain to engineered vascular constructs made of isolated smooth muscle cells in a three-dimensional (3D) collagen type 1 matrix. Platelet-derived growth factor (PDGF) and transforming growth factor beta (TGF-beta) were added exogenously to the ...
journal_title:Annals of biomedical engineering
pub_type: 杂志文章
doi:10.1114/1.1558031
更新日期:2003-04-01 00:00:00
abstract::A solid tumor is composed of a population of cells that is expanding as a result of cell division. With dense cell packing, the solid matrix of the interstitial tissue is subject to residual stress. In addition, elevated interstitial fluid pressure (IFP) has been reported by researchers for a number of solid tumors. T...
journal_title:Annals of biomedical engineering
pub_type: 杂志文章
doi:10.1114/1.1554923
更新日期:2003-03-01 00:00:00
abstract::The design and operating characteristics of the first self-contained in-the-ear device to deliver altered auditory feedback is described for applications with those who stutter. The device incorporates a microdigital signal processor core that reproduces the high fidelity of unaided listening and auditory self-monitor...
journal_title:Annals of biomedical engineering
pub_type: 杂志文章
doi:10.1114/1.1541014
更新日期:2003-02-01 00:00:00
abstract::Recent studies have demonstrated the ability of magnetic resonance imaging (MRI) to provide anatomically realistic boundary conditions for computational fluid dynamics (CFD) simulations of arterial hemodynamics. To date, however, little is known about the overall reproducibility of such image-based CFD techniques. Tow...
journal_title:Annals of biomedical engineering
pub_type: 临床试验,杂志文章
doi:10.1114/1.1540102
更新日期:2003-02-01 00:00:00
abstract::One goal of large scale clinical trials is to determine how a drug is processed by, and cleared from, the human body [i.e., its pharmacokinetic (PK) properties] and how these PK properties differ between individuals in a population (i.e., its population PK properties). Due to the high cost of these studies and the lim...
journal_title:Annals of biomedical engineering
pub_type: 杂志文章
doi:10.1114/1.1533074
更新日期:2003-01-01 00:00:00
abstract::The objective of this study was to develop a unique device for applying well-characterized cyclic, strain to cells growing on implant alloys. The device is based on the four-point bending principle and utilizes an electric motor, belt, and cam system to cyclically deflect a commercially pure titanium plate with cell c...
journal_title:Annals of biomedical engineering
pub_type: 杂志文章
doi:10.1114/1.1529195
更新日期:2002-11-01 00:00:00
abstract::Examining students' learning styles can yield information useful to the design of learning activities, courses, and curricula. A variety of measures have been used to characterize learning styles, but the literature contains little information specific to biomedical engineering (BMEN) students. We, therefore, utilized...
journal_title:Annals of biomedical engineering
pub_type: 杂志文章
doi:10.1114/1.1512677
更新日期:2002-09-01 00:00:00
abstract::Recently, we reported that tethering and rolling of neutrophils in shear flow over a substrate of E-selectin signals activation of beta 2-integrins and firm adhesion via an intracellular signaling pathway involving phosphorylation of p38 MAP kinase. In the current study the objective was to examine the molecular mecha...
journal_title:Annals of biomedical engineering
pub_type: 杂志文章
doi:10.1114/1.1511240
更新日期:2002-09-01 00:00:00
abstract::An endovascular technique using a stent has been developed and successfully applied in the treatment of wide neck aneurysms. A stent can facilitate thrombosis in the aneurysm pouch while maintaining biocompatible passage of the parent artery. Insertion of the stent changes the flow characteristics inside the aneurysm ...
journal_title:Annals of biomedical engineering
pub_type: 杂志文章
doi:10.1114/1.1500406
更新日期:2002-07-01 00:00:00
abstract::Femoral neck fractures are a relevant clinical and social problem. The aim of this study was to improve the prediction of patients at-risk of femoral neck fracture with respect to the current densitometric-based methods. In particular, finite element models were used to assess the prediction accuracy obtained by combi...
journal_title:Annals of biomedical engineering
pub_type: 杂志文章
doi:10.1114/1.1495866
更新日期:2002-06-01 00:00:00
abstract::The traditional auscultatory technique and current methodologies for measuring human blood pressure are limited when used in situations where extreme vibration or acoustic noise is present. In this study, human subjects were used to establish the effectiveness of a novel adaptive blood pressure monitoring (ABPM) syste...
journal_title:Annals of biomedical engineering
pub_type: 临床试验,杂志文章
doi:10.1114/1.1481051
更新日期:2002-05-01 00:00:00
abstract::Local hemodynamics are an important factor in atherosclerosis, from the development of early lesions, to the assessment of stroke risk, to determining the ultimate fate of a mature plaque. Until recently, our understanding of arterial fluid dynamics and their relationship to atherosclerosis was limited by the use of i...
journal_title:Annals of biomedical engineering
pub_type: 杂志文章,评审
doi:10.1114/1.1467679
更新日期:2002-04-01 00:00:00
abstract::The neutrophil has developed into one of the most efficient vertebrate motile cells. It migrates through tissues, where it encounters multiple chemoattractant signals with complex spatial and temporal characteristics. The directional movement of the neutrophil is signaled by the binding of chemoattractants and chemoki...
journal_title:Annals of biomedical engineering
pub_type: 杂志文章,评审
doi:10.1114/1.1477446
更新日期:2002-03-01 00:00:00
abstract::An intelligent multichannel stimulator (IMS) has been designed and built for use in a cardiac research environment. The device is capable of measuring and responding to cardiac electrophysiological phenomena in real time with carefully timed and placed electrical stimuli. The system consists of 16 channels of sense/st...
journal_title:Annals of biomedical engineering
pub_type: 杂志文章
doi:10.1114/1.1451077
更新日期:2002-02-01 00:00:00
abstract::Similarities between photoreceptor Kx channels and EAG and KCNQ channels suggest that the Kx channel may be related to one or both of these families of potassium channels. To provide a basis for further comparison of these channels, as well as to reveal the role of zinc (endogenously present in photoreceptors) in Kx c...
journal_title:Annals of biomedical engineering
pub_type: 杂志文章
doi:10.1114/1.1521415
更新日期:2002-01-01 00:00:00
abstract::We propose a multifrequency energy transmission scheme for annular phased arrays in deep-body hyperthermia. The problem of frequency dependent resonance effects reported in hyperthermia phantom calibration studies, leading to skewed energy deposition patterns and unwanted energy maxima (hot spots), is addressed by com...
journal_title:Annals of biomedical engineering
pub_type: 杂志文章
doi:10.1114/1.1430749
更新日期:2002-01-01 00:00:00
abstract::Radiation applied for therapy and diagnostics damages molecular/atomic couples of biotissues, bones being among them. As a result, electron peculiarities and mechanical behavior of the latter are altered. Correlation between strength of the irradiated bone and its electron features explored due to photo- and exoelectr...
journal_title:Annals of biomedical engineering
pub_type: 杂志文章,评审
doi:10.1114/1.1424911
更新日期:2001-12-01 00:00:00
abstract::Normalized maximal ventricular power (nPWRmax) is an index of cardiac function which measures the innate blood pumping ability, or contractility, of the left ventricle (LV), and its noninvasive assessment could prove useful in a variety of patients. nPWRmax is defined as the maximum instantaneous product of LV pressur...
journal_title:Annals of biomedical engineering
pub_type: 临床试验,杂志文章
doi:10.1114/1.1415530
更新日期:2001-11-01 00:00:00
abstract::We describe a system for real-time control of biological and other experiments. This device, based around the Real-Time Linux operating system, was tested specifically in the context of dynamic clamping, a demanding real-time task in which a computational system mimics the effects of nonlinear membrane conductances in...
journal_title:Annals of biomedical engineering
pub_type: 杂志文章
doi:10.1114/1.1408929
更新日期:2001-10-01 00:00:00
abstract::Diabetic retinopathy is the leading cause of blindness in working age individuals in the United States. Breakdown of the blood-retinal barrier is one of the earliest events in the progression of diabetic retinopathy. Ideally, therapeutic measures would be directed at this early stage, but there are few sensitive, quan...
journal_title:Annals of biomedical engineering
pub_type: 杂志文章
doi:10.1114/1.1385809
更新日期:2001-08-01 00:00:00
abstract::Early stage changes in hypertensive arteries have a significant effect on the long-term adaptation of the arteries. Compared to the long-term adaptation, little is known about the early dimensional and functional changes in hypertensive arteries in the first few days of hypertension. To study the early stage changes i...
journal_title:Annals of biomedical engineering
pub_type: 杂志文章
doi:10.1114/1.1376391
更新日期:2001-06-01 00:00:00
abstract::To better understand the relationship between kinetic processes of contraction and the dynamic features of an isometric twitch, studies were conducted using a mathematical model that included: (1) kinetics of cross bridge (XB) cycling; (2) kinetics of thin filament regulatory processes; (3) serial and feedback interac...
journal_title:Annals of biomedical engineering
pub_type: 杂志文章
doi:10.1114/1.1366669
更新日期:2001-05-01 00:00:00
abstract::Static and dynamic components of the stretch reflex were studied in elbow flexors of 13 hemiparetic brain-injured individuals. Constant-velocity joint rotations were applied to the elbow, and the resulting stretch reflex torque and electromyographic responses were recorded in the biceps brachii and brachioradialis mus...
journal_title:Annals of biomedical engineering
pub_type: 杂志文章
doi:10.1114/1.1359496
更新日期:2001-04-01 00:00:00
abstract::The nonlinear dynamic properties of action potential encoding were studied in mechanosensory neurons innervating the slits of a slit-sense organ in the tropical wandering spider, Cupiennius salei. The organ contains two types of neurons that are morphologically similar but have different dynamic properties. Type A neu...
journal_title:Annals of biomedical engineering
pub_type: 杂志文章
doi:10.1114/1.1355278
更新日期:2001-03-01 00:00:00